化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1922221作成日：2026年10月27日
Cyclohexanemethylamine → 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide
https://huagongshe.com/reaction/1922221
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyclohexanemethylamine | HCID 76688 | — |
| 反応物 | 2-Pyridinecarboxamide, N-methyl-4-[[2-(methylsulfinyl)-6-benzothiazolyl]oxy]- | HCID 57725393 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-[2-(Cyclohexylmethyl-amino)-benzothiazol-6-yloxy]-pyridine-2-carboxylic acid methylamide | HCID 57725483 | — |
反応手順
To the solution of 4-(2-methanesulfinyl-benzothiazol-6-yloxy)-pyridine-2-carboxylic acid methylamide (25 mg, 0.072 mmol, 1.0 eq) in DMF (500 μL), was added cyclohexylmethylamine (18.7 μL, 0.144 mmol, 2.0 eq) and reaction was stirred at 70° C. overnight. The neat reaction mixture was purified on reverse phase preparatory HPLC. Pure fractions were lyophilized as TFA salts. M+H=397.1
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08173689B2 |
|---|
| 出典データセット | uspto-grants-2012_05 |
|---|
| ORD ID | ord-905c8fbe415a4e8ebaca37635996971e |
|---|
| 出典メモ | uspto-grants-2012_05 |
|---|
