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HRID 1922241作成日：2026年10月27日
Diisopropylethylamine → (S)-tert-butyl 3-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate
https://huagongshe.com/reaction/1922241
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | tert-butyl (3S)-3-aminopiperidine-1-carboxylate | HCID 1501975 | — |
| 反応物 | 6-(2-Chloropyridin-4-yloxy)-2-(methylsulfinyl)benzo[d]thiazole | HCID 57725430 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | (S)-tert-butyl 3-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate | HCID 57725807 | 112% |
反応手順
To the solution of 6-(2-chloropyridin-4-yloxy)-2-(methylsulfinyl)benzo[d]thiazole (100 mg, 0.31 mmol) in 1.6 ml of NMP was added (S)-tert-butyl 3-aminopiperidine-1-carboxylate (200 mg, 1 mmol) and DIPEA (70 μL, 0.4 mmol). The reaction solution was stirred at 95° C. for 5 days. The crude reaction solution was purified on prep HPLC and evaporated in vacuo to give (S)-tert-butyl 3-(6-(2-chloropyridin-4-yloxy)benzo[d]thiazol-2-ylamino)piperidine-1-carboxylate (160 mg) as TFA salt. ES/MS m/z 461.1 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08173689B2 |
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| 出典データセット | uspto-grants-2012_05 |
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| ORD ID | ord-bab238fbc0ab41268fc5226ff554d1dd |
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| 出典メモ | uspto-grants-2012_05 |
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