Methyl quinuclidin-3-ylideneacetate hydrochloride → 2-(1-Azabicyclo(2.2.2)octan-3-ylidene)acetic acid hydrochloride

HRID 1923399ノート

反応式

HRID 1923399 の反応式
[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C:4](=[CH:10][C:11]([O:13]C)=[O:12])[CH2:3]2>Cl>[ClH:1].[N:2]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[C:4](=[CH:10][C:11]([OH:13])=[O:12])[CH2:3]2

参加物

3

反応物 1

HCID 67401072Methyl quinuclidin-3-ylideneacetate hydrochloride

生成物 1

HCID 674019582-(1-Azabicyclo(2.2.2)octan-3-ylidene)acetic acid hydrochloride

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Methyl quinuclidin-3-ylideneacetate hydrochloride (1 g) was heated in concentrated hydrochloric acid (10 ml) at 60° C. for 18 hrs and the solution evaporated to dryness. The residue was kept under vacuum over P2O5 for 3 days to give quinuclidin-3-ylidene acetic acid hydrochloride, 0.91 g (97%) as a white solid; 1H NMR (D2O) inter alia 5.77 (broad s) and 5.86 (broad s) (ca. 1:1, vinyl protons of the two geom. isomers).

後処理

  1. customthe solution evaporated to dryness

出典と根拠

ORDレコード
ord-f8aea18b20ae4bfba7d3591f0e2727aa
出典データセット
uspto-grants-2012_05
特許番号
USRE043390E1

反応ノート

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