(3-Dibenzylamino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester → Phosphonic acid, P-(3-amino-2-hydroxy-5-methylhexyl)-, dimethyl ester
反応式
[CH3:1][O:2][P:3]([CH2:7][CH:8]([OH:29])[CH:9]([N:14](CC1C=CC=CC=1)CC1C=CC=CC=1)[CH2:10][CH:11]([CH3:13])[CH3:12])(=[O:6])[O:4][CH3:5]>CO.[C].[Pd]>[CH3:1][O:2][P:3]([CH2:7][CH:8]([OH:29])[CH:9]([NH2:14])[CH2:10][CH:11]([CH3:12])[CH3:13])(=[O:6])[O:4][CH3:5]参加物
4
反応条件
- 温度
- 39.5 °C
実験手順
Reaction 4: A diastereomeric mixture of the crude (3-dibenzylamino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester, compound 4, obtained in reaction 3, was treated with palladium-carbon (2.0% wt) as the catalyst in methanol (40 mL). The mixture reaction was stirred for 12 h under a hydrogen gas atmosphere at 37-42° C., and after this period of time, the mixture was filtered through a pad of Celite, and the solvents were removed under reduced pressure to leave (3-amino-2-hydroxy-5-methyl-hexyl)-phosphonic acid dimethyl ester, compound 5, as a crude oil.