4-Carboxychalcone → HCID 22251491、化合物

HRID 1923465ノート

反応式

HRID 1923465 の反応式
[O:1]=[C:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH:3]=[CH:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1>[Ni].C(O)C>[O:1]=[C:2]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH2:3][CH2:4][C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1

参加物

4

反応物 1

HCID 39957814-Carboxychalcone

生成物 1

HCID 22251491HCID 22251491、化合物収率 59.9%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

4-(3-Oxo-3-phenyl-propenyl)-benzoic acid (7.64 g, 30 mmol) is combined with Raney nickel (2 g) in ethanol (140 mL). The mixture is hydrogenated at room temperature and 50 psi for 1.5 h. The reaction is filtered evaporated in vacuo. The resulting residue is recrystallized from ethyl acetate to obtain 4.57 g (59%) of the titled compound. m.p.=145-147° C.; Anal. Calcd for C16H14O3: C, 75.58; H, 5.55. Found: C, 75.60; H, 5.32.

後処理

  1. customis hydrogenated at room temperature
  2. filtrationThe reaction is filtered
  3. customevaporated in vacuo
  4. customThe resulting residue is recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-d8ef56805cad48769ca5617b918e30b8
出典データセット
uspto-grants-2012_05
特許番号
US08178528B2

反応ノート

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