Hydrochloric Acid → N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hydrochloride

HRID 1924024ノート

反応式

HRID 1924024 の反応式
[CH3:1][C@@H:2]1[N:7]([CH2:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17]3[N:22]=[C:21]([C:23]4[N:27]([CH:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[C:26]([CH3:34])=[N:25][CH:24]=4)[C:20]([F:35])=[CH:19][N:18]=3)=[C:11]([F:36])[CH:10]=2)[C@@H:6]([CH3:37])[CH2:5][O:4][CH2:3]1.[ClH:38]>ClCCl>[ClH:38].[CH3:1][C@@H:2]1[N:7]([CH2:8][C:9]2[C:14]([F:15])=[CH:13][C:12]([NH:16][C:17]3[N:22]=[C:21]([C:23]4[N:27]([CH:28]5[CH2:33][CH2:32][O:31][CH2:30][CH2:29]5)[C:26]([CH3:34])=[N:25][CH:24]=4)[C:20]([F:35])=[CH:19][N:18]=3)=[C:11]([F:36])[CH:10]=2)[C@@H:6]([CH3:37])[CH2:5][O:4][CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 49782014N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine

生成物 1

HCID 49782252N-(4-(((3S,5S)-3,5-Dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine hydrochloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

N-(4-(((3S,5S)-3,5-dimethylmorpholino)methyl)-2,5-difluorophenyl)-5-fluoro-4-(2-methyl-1-(tetrahydro-2H-pyran-4-yl)-1H-imidazol-5-yl)pyrimidin-2-amine (16 mg) was dissolved in dichloromethane (4 ml) and HCl (1M in diethyl ether, 0.05 ml) was added. The solvents were evaporated to give the title compound (0.015 g) as a solid.

後処理

  1. customThe solvents were evaporated

出典と根拠

ORDレコード
ord-41addefe23d442708ddf864b4c61529d
出典データセット
uspto-grants-2012_05
特許番号
US08178529B2

反応ノート

読み込み中…