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4-Chlorophenylglyoxylic acid → 2-(4-chlorophenyl)-4-cyclopropylmethylpyrido[2,3-b]pyrazin-3(4H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorophenylglyoxylic acid | HCID 145998 | — |
| 反応物 | N2-(cyclopropylmethyl)pyridine-2,3-diamine | HCID 28902457 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(4-chlorophenyl)-4-cyclopropylmethylpyrido[2,3-b]pyrazin-3(4H)-one | HCID 44218437 | 36.6% |
反応手順
430 mg (2.63 mM) of N2-(cyclopropylmethyl)pyridine-2,3-diamine and 485.4 mg (2.63 mM) of (4-chlorophenyl)(oxo)acetic acid in 6 ml of methanol were refluxed for 16 h. A solid crystallized. The compound was filtered and washed with methanol to give 300 mg of 2-(4-chlorophenyl)-4-(cyclopropylmethyl)pyrido[2,3-b]pyrazin-3(4H)-one as a beige solid. Yield: 36.5%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08178556B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-52a91adbeb404db9abcfa749d74086e7 |
| 出典メモ | uspto-grants-2012_05 |