Hydrochloric Acid → 1-Phenyl-3-(2-o-tolyl-2H-pyrazol-3-yl)-1H-pyridazin-4-one

反応式

C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:8]=1)=O.[C:21]1([CH3:29])[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[NH:27]N.Cl>>[C:14]1([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:27]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[CH3:29])[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 68256o-Tolylhydrazine

HCID 12742246(E)-3-(3-(Dimethylamino)acryloyl)-1-phenylpyridazin-4(1H)-one

生成物 1

HCID 462191921-Phenyl-3-(2-o-tolyl-2H-pyrazol-3-yl)-1H-pyridazin-4-one収率 55%

実験手順

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-phenyl-1H-pyridazin-4-one (A-1) and o-tolylhydrazine×HCl according to the method described for Example 1 in 55% yield. MS: M=329.1 (M+H)+