4-(Methylsulphonyl)phenylhydrazine → 1-(3-Ethyl-phenyl)-3-[2-(4-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one

HRID 1924500

反応式

HRID 1924500 の反応式
C[N:2](C)/[CH:3]=[CH:4]/[C:5]([C:7]1[C:12](=[O:13])[CH:11]=[CH:10][N:9]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH2:20][CH3:21])[CH:15]=2)[N:8]=1)=O.[CH3:23][S:24]([C:27]1[CH:32]=[CH:31][C:30]([NH:33]N)=[CH:29][CH:28]=1)(=[O:26])=[O:25]>>[CH2:20]([C:16]1[CH:15]=[C:14]([N:9]2[CH:10]=[CH:11][C:12](=[O:13])[C:7]([C:5]3[N:33]([C:30]4[CH:29]=[CH:28][C:27]([S:24]([CH3:23])(=[O:26])=[O:25])=[CH:32][CH:31]=4)[N:2]=[CH:3][CH:4]=3)=[N:8]2)[CH:19]=[CH:18][CH:17]=1)[CH3:21]

参加物

3

反応物 2

HCID 701424-(Methylsulphonyl)phenylhydrazineHCID 593701083-((E)-3-Dimethylamino-acryloyl)-1-(3-ethyl-phenyl)-1H-pyridazin-4-one

生成物 1

HCID 462193191-(3-Ethyl-phenyl)-3-[2-(4-methanesulfonyl-phenyl)-2H-pyrazol-3-yl]-1H-pyridazin-4-one収率 50%

実験手順

The product was obtained starting from 3-((E)-3-Dimethylamino-acryloyl)-1-(3-ethyl-phenyl)-1H-pyridazin-4-one (A-4) and 4-(methylsulfonyl)phenylhydrazine according to the method described for Example 1 in 50% yield. MS: M=421.1 (M+H)+

後処理

  1. customThe product was obtained

出典と根拠

ORDレコード
ord-7c06988d7c804cdca8f4284881283d7e
出典データセット
uspto-grants-2012_05
特許番号
US08178538B2

関連ノート

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