Hydrochloric Acid → 5-(2,4-dimethyl-1,3-thiazol-5-yl)-2,4(1H,3H)-pyrimidinedione
反応式
[CH3:1][C:2]1[S:3][C:4]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[C:5]([CH3:7])[N:6]=1.Cl>CO>[CH3:1][C:2]1[S:3][C:4]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[C:5]([CH3:7])[N:6]=1参加物
4
実験手順
5-(2,4-dimethyl-1,3-thiazol-5-yl)-2,4-bis(methyloxy)pyrimidine (521 mg, 2.073 mmol) was dissolved in Methanol (30 ml), then 1N Hydrochloric acid aqueous solution (16.59 ml, 16.59 mmol) was added and the mixture was refluxed for 3 hours. Solvents were then evaporated under reduced pressure, the residue was triturated with acetone and filtered providing the title compound (507 mg, 2.27 mmol) as a white solid.
後処理
- temperaturethe mixture was refluxed for 3 hours
- customSolvents were then evaporated under reduced pressure
- customthe residue was triturated with acetone
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-82e84b6163024e18ac02addab0dae7f9
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178549B2
反応ノート
読み込み中…