2,4-Bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine → 5-(4-methyl-1,3-thiazol-2-yl)-2,4(1H,3H)-pyrimidinedione
反応式
C[O:2][C:3]1[N:8]=[C:7]([O:9]C)[C:6]([C:11]2[S:12][CH:13]=[C:14]([CH3:16])[N:15]=2)=[CH:5][N:4]=1>Cl.O1CCOCC1>[CH3:16][C:14]1[N:15]=[C:11]([C:6]2[C:7](=[O:9])[NH:8][C:3](=[O:2])[NH:4][CH:5]=2)[S:12][CH:13]=1参加物
4
反応条件
- 温度
- 90 °C
実験手順
2,4-bis(methyloxy)-5-(4-methyl-1,3-thiazol-2-yl)pyrimidine (Prep40, 280 mg, 0.861 mmol) was dissolved in 18 mL of hydrochloric acid 4M in dioxane and the resulting mixture was stirred in a round bottomed flask at 90° C. for 2 hours. Then it was cooled to rt and dried under vacuum to afford the title compound as a yellow solid (300 mg, 0.760 mmol)
後処理
- temperatureThen it was cooled to rt
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-94e95d24e6f843b79c08b737dba71578
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178549B2
反応ノート
読み込み中…