Hydrochloric Acid → 5-(3-methyl-4-isothiazolyl)-2,4(1H,3H)-pyrimidinedione
反応式
[CH3:1][C:2]1[C:6]([C:7]2[C:8]([O:15]C)=[N:9][C:10]([O:13]C)=[N:11][CH:12]=2)=[CH:5][S:4][N:3]=1.Cl>O1CCOCC1>[CH3:1][C:2]1[C:6]([C:7]2[C:8](=[O:15])[NH:9][C:10](=[O:13])[NH:11][CH:12]=2)=[CH:5][S:4][N:3]=1参加物
4
実験手順
5-(3-methyl-4-isothiazolyl)-2,4-bis(methyloxy)pyrimidine (Prep 46, two batches combined, 30 mg, 0.148 mmol) was suspended in a 4M solution of HYDROCHLORIC ACID (1580 μl, 6.32 mmol) in dioxane the mixture was stirred at 90° for 2.5 hours. The mixture was allowed to cool to rt and dried (rotary) to afford a yellowish solid (0.126 mmol, yield considered quantitative assuming complete conversion to target compound).
後処理
- customdried (rotary)
- customto afford
- customa yellowish solid (0.126 mmol, yield considered quantitative assuming complete conversion to target compound)
出典と根拠
- ORDレコード
- ord-a2bdbb69e4a343aaba0f0dac2a46e53d
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178549B2
反応ノート
読み込み中…