化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → Ziprasidone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | Ziprasidone Hydrochloride | HCID 219099 | — |
| 反応物 | 3-(1-Piperazinyl)-1,2-benzisothiazole | HCID 2772144 | — |
| 反応物 | 5-(2-Chloroethyl)-6-chlorooxindole | HCID 10609474 | — |
| 溶媒 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 生成物 | Ziprasidone | HCID 60854 | — |
反応手順
U.S. Pat. No. 4,831,031 discloses a process for the preparation of ziprasidone hydrochloride, which involves refluxing N-(1,2-benzisothiazol-3-yl)piperazine with 5-(2-chloroethyl)-6-chloro-oxindole in methyl isobutyl ketone in the presence of sodium iodide and sodium carbonate for about 40 hours followed by column chromatographic purification of the product to get ziprasidone base which is dissolved in methylene chloride and treated with ethereal hydrogen chloride to get ziprasidone hydrochloride salt. The salt is washed with acetone and the product is dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08178674B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-a1fe5bcacab64580aac065d315eeeb4c |
| 出典メモ | uspto-grants-2012_05 |