Ethanol → Ethyl 3-(3-hydroxyphenyl)propanoate
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:8]([CH3:12])C(O)=O)[CH:5]=[CH:6][CH:7]=1.[OH2:13].[C:14]1([CH3:24])C=CC(S(O)(=O)=O)=CC=1.[CH2:25]([OH:27])C>>[OH:1][C:2]1[CH:3]=[C:4]([CH2:8][CH2:12][C:25]([O:27][CH2:14][CH3:24])=[O:13])[CH:5]=[CH:6][CH:7]=1参加物
4
実験手順
A solution of 3-Hydroxyphenylpropanoic acid (25 g, 150.60 mmol) and p-Toluenesulfonic acid monohydrate (3.80 g, 20 mmol) in abs ethanol (250 ml) was refluxed for 4 hours or until all the starting material is consumed. The reaction mixture was concentrated, diluted with ethyl acetate and washed with water. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex:ethyl acetate 2:1) to give the title compound.
後処理
- customis consumed
- concentrationThe reaction mixture was concentrated
- additiondiluted with ethyl acetate
- washwashed with water
- dry with materialThe organic layer was dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- custompurified by flash chromatography on a silica gel column (hex:ethyl acetate 2:1)
出典と根拠
- ORDレコード
- ord-20b135e5414c4a0c9a10063968dc63f0
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178675B2
反応ノート
読み込み中…