P-Anisidine → 2-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

反応式

[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.CO[CH:12]=[C:13]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:14]([O:16][CH2:17][CH3:18])=[O:15]>>[CH3:1][O:2][C:3]1[CH:9]=[CH:8][C:6]([NH:7][CH:12]=[C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:5][CH:4]=1

参加物

反応物 2

HCID 7732P-Anisidine

HCID 3016162Diethyl methoxymethylenemalonate

生成物 1

HCID 6189812-((4-Methoxy-phenylamino)-methylene)-malonic acid diethyl ester

反応条件

温度: 100 °C

実験手順

In a flask maintained under reduce pressure, p-methoxyaniline (35.1 g, 280 mmol) and diethyl 2-(methoxymethylene)malonate (73.97 g, 340 mmol) were stirred at 100° C. for two h. The crude mixture was used without further purification.

後処理

temperatureIn a flask maintained
customThe crude mixture was used without further purification

出典と根拠

ORDレコード: ord-005deeca3c1b44e79a1908868992c54f
出典データセット: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08178557B2

反応ノート

読み込み中…

参加物