Tert-butyl (2-{4-[2-(1-adamantyl)ethoxy]phenyl}ethyl)-carbamate → (2-{4-[2-(1-Adamantyl)ethoxy]phenyl}ethyl)amine

HRID 1925496ノート

反応式

HRID 1925496 の反応式
[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22]C(=O)OC(C)(C)C)=[CH:16][CH:15]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2>Cl.CO>[C:1]12([CH2:11][CH2:12][O:13][C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH2:22])=[CH:16][CH:15]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2

参加物

4

反応物 1

HCID 86649157Tert-butyl (2-{4-[2-(1-adamantyl)ethoxy]phenyl}ethyl)-carbamate

生成物 1

HCID 67520640(2-{4-[2-(1-Adamantyl)ethoxy]phenyl}ethyl)amine

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

実験手順

Obtained from Intermediate 21 (0.167 g, 1.42 mmol) in hydrogen chloride 1.25M in methanol by the same procedure described in Intermediate 17. The solvent was removed to give the title compound as a white solid salt (0.127 g, 98%), which was used in the next step without further purification. MS (M+): 300.

後処理

  1. customThe solvent was removed

出典と根拠

ORDレコード
ord-d5fcafff68ed4960823637c5680dca13
出典データセット
uspto-grants-2012_05
特許番号
US08178679B2

反応ノート

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