9-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid (4-aminopyridin-3-yl)amide → HCID 67072884、化合物

HRID 1925572

反応式

HRID 1925572 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][C:3]=1[NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:19]=1[N:18]1[CH:20]=[CH:21][CH:22]=[C:17]1[C:16]2=[O:23])=O>C(O)(=O)C>[N:1]1[C:2]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[NH:8][C:9]=1[C:11]1[C:19]2[N:18]3[CH:20]=[CH:21][CH:22]=[C:17]3[C:16](=[O:23])[C:15]=2[CH:14]=[CH:13][CH:12]=1

参加物

3

反応物 1

HCID 672993589-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid (4-aminopyridin-3-yl)amide

生成物 1

HCID 67072884HCID 67072884、化合物収率 46.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
200 °C

実験手順

In a 20 ml microwave reactor, a mixture of 256 mg of 9-oxo-9H-pyrrolo[1,2-a]indole-5-carboxylic acid (4-aminopyridin-3-yl)amide obtained according to the preceding stage, in 20 ml of glacial acetic acid, is heated at 200° C. for 30 minutes. The reaction medium is filtered through clarcel, washing being carried out with glacial acetic acid. The filtrate is evaporated to dryness under vacuum and the residue is taken up twice with toluene and each time re-evaporated to dryness under vacuum. The solid is triturated from isopropyl ether, filtered, and dried under vacuum at 40° C. overnight. 111 mg of 5-(3H-imidazo[4,5-c]pyridin-2-yl)pyrrolo[1,2-a]indol-9-one are obtained in the form of a solid, the characteristics of which are the following:

後処理

  1. customobtained
  2. filtrationThe reaction medium is filtered through clarcel
  3. washwashing
  4. customThe filtrate is evaporated to dryness under vacuum
  5. customeach time re-evaporated to dryness under vacuum
  6. customThe solid is triturated from isopropyl ether
  7. filtrationfiltered
  8. customdried under vacuum at 40° C. overnight

出典と根拠

ORDレコード
ord-cd8eeddff9144481bd321ffc907f4d29
出典データセット
uspto-grants-2012_05
特許番号
US08178687B2

関連ノート

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