Hydrochloric Acid → N-(4-butyl-2-chlorophenyl)acetamide

HRID 1925712ノート

反応式

HRID 1925712 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)[CH2:2][CH2:3][CH3:4].[Cl:15]N1C(=O)CCC1=O.Cl>CN(C)C=O>[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[C:7]([Cl:15])[CH:6]=1)[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 31398ChlorosuccinimideHCID 77227Acetamide, N-(4-butylphenyl)-

生成物 1

HCID 59180380N-(4-butyl-2-chlorophenyl)acetamide収率 103.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

A mixture of 67 (7.0 g; 36.6 mmol) and N-chlorosuccinimide (7.8 g; 58.6 mmol) was dissolved in N,N-dimethylformamide (70 mL). The reaction was heated at 70° C. for 6 hours, cooled to room temperature, then poured into aqueous hydrochloric acid (400 mL; 2M), and stirred for 15 minutes. The resulting precipitate was isolated by filtration and dried under vacuum to give the title product as an orange solid (8.54 g).

後処理

  1. temperaturecooled to room temperature
  2. customThe resulting precipitate was isolated by filtration
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-ad311ba304954a8f86fa6dafa422b20e
出典データセット
uspto-grants-2012_05
特許番号
US08178699B2

反応ノート

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