Hydrochloric Acid → 2-Chloro-4-butylaniline

HRID 1925713ノート

反応式

HRID 1925713 の反応式
[CH2:1]([C:5]1[CH:10]=[CH:9][C:8]([NH:11]C(=O)C)=[C:7]([Cl:15])[CH:6]=1)[CH2:2][CH2:3][CH3:4].Cl.[OH-].[K+]>C(O)C>[Cl:15][C:7]1[CH:6]=[C:5]([CH2:1][CH2:2][CH2:3][CH3:4])[CH:10]=[CH:9][C:8]=1[NH2:11]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 59180380N-(4-butyl-2-chlorophenyl)acetamide

生成物 1

HCID 211613422-Chloro-4-butylaniline収率 84.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
120 °C

実験手順

To a suspension of 68 (8.54 g; 37.9 mmol) in ethanol (20 mL) was added concentrated hydrochloric acid (20 mL). The resulting mixture was heated at 120° C. for 5 hours, allowed to cool to room temperature, then made basic with aqueous potassium hydroxide, and extracted with methyl tert-butyl ether (3×75 mL). The combined organic extracts were washed with aqueous saturated sodium chloride, dried over sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure to give the title product as a dark oil (5.89 g).

後処理

  1. temperatureto cool to room temperature
  2. extractionextracted with methyl tert-butyl ether (3×75 mL)
  3. washThe combined organic extracts were washed with aqueous saturated sodium chloride
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-2a1e8f0751c24a8d88eed05c66fad08d
出典データセット
uspto-grants-2012_05
特許番号
US08178699B2

反応ノート

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