2,5-Dichloro-1,3-benzothiazole → 2-Chloro-7-methyl-1,3-benzothiazole
反応式
F[C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].SC1SC2C(C)=CC=CC=2N=1.[Cl:21][C:22]1[S:23]C2C=CC(Cl)=CC=2N=1>>[Cl:21][C:22]1[S:23][C:2]2[C:8]([CH3:9])=[CH:7][CH:6]=[CH:5][C:3]=2[N:4]=1参加物
4
反応条件
- 温度
- 180 °C
実験手順
The title compound was prepared from 2-fluoro-3-methylaniline via 2-mercapto-7-methyl-1,3-benzothiazole as described for 2,5-dichloro-1,3-benzothiazole except that in the first step the reaction mixture was heated to 180° C. for 24 h in a sealed tube.
出典と根拠
- ORDレコード
- ord-485efb7d20e24fa096649e1404ecc564
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08178668B2
反応ノート
読み込み中…