4-Chloro-5-fluoro-2-methoxypyrimidine → HCID 59333920、化合物

HRID 1927005ノート

反応式

HRID 1927005 の反応式
[CH2:1]([N:3]1[C@H:8]([CH3:9])[CH2:7][N:6]([C:10]([N:12]2[CH2:19][C:18]3[C:17]([NH2:20])=[N:16][NH:15][C:14]=3[C:13]2([CH3:22])[CH3:21])=[O:11])[C@@H:5]([CH3:23])[CH2:4]1)[CH3:2].Cl[C:25]1[C:30]([F:31])=[CH:29][N:28]=[C:27]([O:32][CH3:33])[N:26]=1>C(O)(=O)C.O>[CH2:1]([N:3]1[C@H:8]([CH3:9])[CH2:7][N:6]([C:10]([N:12]2[CH2:19][C:18]3[C:17]([NH:20][C:25]4[C:30]([F:31])=[CH:29][N:28]=[C:27]([O:32][CH3:33])[N:26]=4)=[N:16][NH:15][C:14]=3[C:13]2([CH3:22])[CH3:21])=[O:11])[C@@H:5]([CH3:23])[CH2:4]1)[CH3:2]

参加物

5

反応物 2

HCID 534398964-Chloro-5-fluoro-2-methoxypyrimidineHCID 59333925HCID 59333925、化合物

生成物 1

HCID 59333920HCID 59333920、化合物

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

実験手順

A solution of 5-{[(2S,5R)-4-ethyl-2,5-dimethylpiperazin-1-yl]carbonyl}-6,6-dimethyl-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-amine (289 mg, 0.9 mmol) and 4-chloro-5-fluoro-2-methoxypyrimidine (257 mg, 2 eq) in 5 mL of 50% acetic acid in water was heated in a microwave for 30 min at 80° C. Purification as described in Example A1 afforded the title compound AA1 as a white powder (13.1 mg, 3%). See Table 1 below for NMR data.

後処理

  1. customPurification

出典と根拠

ORDレコード
ord-207d63b8ed8a4c8cb90d16162b3957a7
出典データセット
uspto-grants-2012_05
特許番号
US08183255B2

反応ノート

読み込み中…