Water → Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

HRID 1927291ノート

反応式

HRID 1927291 の反応式
Cl.[NH:2]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=O)[NH2:3].[CH2:13]([O:15][CH:16]=[C:17]([C:20]#N)[C:18]#[N:19])C.[O-:22]CC.[Na+].O>CCO>[CH3:13][O:15][C:16]([C:17]1[CH:20]=[N:3][N:2]2[C:4]3[C:5](=[CH:9][CH:10]=[CH:11][CH:12]=3)[C:6](=[O:8])[NH:19][C:18]=12)=[O:22]

参加物

6

反応物 4

HCID 962WaterHCID 671522-(Ethoxymethylene)propanedinitrileHCID 104169Benzoic acid, 2-hydrazinyl-, hydrochloride (1:1)HCID 2723922Sodium ethoxide

生成物 1

HCID 136389266Methyl-5-oxo-4,5-dihydropyrazolo[1,5-a]quinazoline-3-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-hydrazinylbenzoic acid hydrochloride (10 g, 53 mmol), 2-(ethoxymethylene)malononitrile (6.5 g, 53.2 mmol) and sodium ethoxide (4.85 g, 257 mmol) in EtOH (100 mL) was refluxed overnight then cooled to ambient temperature. Water was added and the mixture was stirred at ambient temperature for 1 h then filtered. The solid was washed with H2O, EtOH and Et2O then dried.

後処理

  1. temperaturewas refluxed overnight
  2. filtrationthen filtered
  3. washThe solid was washed with H2O, EtOH and Et2O
  4. customthen dried

出典と根拠

ORDレコード
ord-391fcd7d3502490dbc94dbabb9bbe8a3
出典データセット
uspto-grants-2012_05
特許番号
US08183250B2

反応ノート

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