Hydrochloric Acid → N-(4,4-dimethylcyclohexyl)-N-{(3S,5S)-5-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-3-yl}acetamide

HRID 1927556ノート

反応式

HRID 1927556 の反応式
C([N:8]1[CH2:12][C@@H:11]([N:13]([C:22](=[O:24])[CH3:23])[CH:14]2[CH2:19][CH2:18][C:17]([CH3:21])([CH3:20])[CH2:16][CH2:15]2)[CH2:10][C@H:9]1[C:25]([N:27]1[CH2:32][CH2:31][N:30]([CH3:33])[CH2:29][CH2:28]1)=[O:26])(OC(C)(C)C)=O.Cl>C(Cl)Cl>[CH3:20][C:17]1([CH3:21])[CH2:18][CH2:19][CH:14]([N:13]([C@H:11]2[CH2:10][C@@H:9]([C:25]([N:27]3[CH2:28][CH2:29][N:30]([CH3:33])[CH2:31][CH2:32]3)=[O:26])[NH:8][CH2:12]2)[C:22](=[O:24])[CH3:23])[CH2:15][CH2:16]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 67359166(2S,4S)-1-BOC-4-[acetyl(4,4-dimethylcyclohexyl)amino]-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidine

生成物 1

HCID 67356954N-(4,4-dimethylcyclohexyl)-N-{(3S,5S)-5-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidin-3-yl}acetamide収率 99.9%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(2S,4S)-1-BOC-4-[acetyl(4,4-dimethylcyclohexyl)amino]-2-[(4-methylpiperazin-1-yl)carbonyl]pyrrolidine (1.06 g, 2.28 mmol) obtained in Step D was dissolved in DCM (1 mL) and 4M HCl (1 mL) was added dropwise thereto. After the reaction solution was stirred at room temperature for 1 hour, the solution was concentrated in vacuo. The residue was concentrated in vacuo to give the title compound (830 mg, 99.8%).

後処理

  1. concentrationthe solution was concentrated in vacuo
  2. concentrationThe residue was concentrated in vacuo

出典と根拠

ORDレコード
ord-01846bbfad694b97a27968d551b140c0
出典データセット
uspto-grants-2012_05
特許番号
US08183243B2

反応ノート

読み込み中…