2-Bromo-1-(3,4-difluorophenyl)ethan-1-one → 4-(3,4-Difluorophenyl)-2-{2-[5-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl}-1,3-thiazole

HRID 1927676

反応式

HRID 1927676 の反応式
[CH3:1][C:2]([CH3:16])([CH2:14][CH3:15])[CH2:3][C:4]1[N:5]=[C:6]([CH2:9][CH2:10][C:11](=[S:13])[NH2:12])[NH:7][CH:8]=1.Br[CH2:18][C:19]([C:21]1[CH:26]=[CH:25][C:24]([F:27])=[C:23]([F:28])[CH:22]=1)=O>C(O)C.O1CCOCC1>[F:28][C:23]1[CH:22]=[C:21]([C:19]2[N:12]=[C:11]([CH2:10][CH2:9][C:6]3[NH:5][C:4]([CH2:3][C:2]([CH3:16])([CH3:1])[CH2:14][CH3:15])=[CH:8][N:7]=3)[S:13][CH:18]=2)[CH:26]=[CH:25][C:24]=1[F:27]

参加物

5

反応物 2

HCID 27370322-Bromo-1-(3,4-difluorophenyl)ethan-1-oneHCID 178442447HCID 178442447、化合物

生成物 1

HCID 594435804-(3,4-Difluorophenyl)-2-{2-[5-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl}-1,3-thiazole

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 312751,4-Dioxane溶媒

実験手順

3-[4-(2,2-Dimethylbutyl)-1H -imidazol-2-yl]propanethioamide (58 mg, 0.24 mmol) in ethanol (1 mL) was added to 2-bromo-1-(3,4-difluorophenyl)ethanone (56 mg, 0.24 mmol) in anhydrous 1,4-dioxane (4 mL). After stirring at rt overnight, the reaction mixture was concentrated to give a residue, which was purified by reverse phase HPLC (KR100-5C18 100×21.2 mm column; 10-100% MeCN/H2O over 12 min) to afford the title compound. LC-MS: m/e 376 (M+H).

後処理

  1. concentrationthe reaction mixture was concentrated
  2. customto give a residue, which
  3. customwas purified by reverse phase HPLC (KR100-5C18 100×21.2 mm column; 10-100% MeCN/H2O over 12 min)

出典と根拠

ORDレコード
ord-d3bf7cc8f6b746fc96b8905cd56e614b
出典データセット
uspto-grants-2012_05
特許番号
US08183275B2

関連ノート

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