Phosphorus oxychloride → 2-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyridine

HRID 1927826ノート

反応式

HRID 1927826 の反応式
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[NH:6][C:5](=O)[CH:4]=1.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][C:5]1[CH:4]=[C:3]([C:2]([F:21])([F:20])[F:1])[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:6]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 574686224-trifluoromethyl-6-(4-trifluoromethylphenyl)-1H-pyridin-2-one

生成物 1

HCID 574686212-Chloro-4-trifluoromethyl-6-(4-trifluoromethylphenyl)-pyridine

実験手順

The title compound was prepared from 4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-1H-pyridin-2-one (51.5 g, 168 mmol) and phosphoryl chloride (50 mL) according to the general procedure Ia to d preparation of chlorides. Obtained as an off-white solid (53.4 g, 98%). MS (ISN) 384.1 [(M+OAc)−], 386.0 [(M+2+OAc)−]; mp 39-40° C.

出典と根拠

ORDレコード
ord-5ce797654f9e4ed1b60bf22b6a84fcaf
出典データセット
uspto-grants-2012_05
特許番号
US08183262B2

反応ノート

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