Phosphorus oxychloride → 2-Chloro-4-(3,4-difluoro-phenyl)-6-trifluoromethyl-pyrimidine
反応式
[F:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[NH:12][C:11](=O)[N:10]=2)[CH:5]=[CH:6][C:7]=1[F:8].O=P(Cl)(Cl)[Cl:22]>>[Cl:22][C:11]1[N:10]=[C:9]([C:4]2[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=2)[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[N:12]=1参加物
3
実験手順
The title compound was prepared from 4-(3,4-difluoro-phenyl)-6-trifluoromethyl-1H-pyrimidin-2-one (14.7 g, 0.053 mol) and phosphoroxychloride (148 mL) according to the general procedure I. Obtained as a light brown solid (15.6 g, 99%). MS (EI) 294.0 [(M)+]; mp 53° C.
出典と根拠
- ORDレコード
- ord-44052153c26446e0b9b25f8d3b68ba6a
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183262B2
反応ノート
読み込み中…