(3-Bromophenyl)boronic acid → 2-(3-Bromo-phenyl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

HRID 1927899ノート

反応式

HRID 1927899 の反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:5]=[C:4]([CH3:15])[N:3]=1.[Br:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1>>[Br:16][C:17]1[CH:22]=[C:21]([C:2]2[N:7]=[C:6]([C:8]3[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=3)[CH:5]=[C:4]([CH3:15])[N:3]=2)[CH:20]=[CH:19][CH:18]=1

参加物

3

反応物 2

HCID 2734318(3-Bromophenyl)boronic acidHCID 202255702-Chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine

生成物 1

HCID 574687612-(3-Bromo-phenyl)-4-(4-chloro-phenyl)-6-methyl-pyrimidine

実験手順

The title compound was prepared from 2-chloro-4-(4-chloro-phenyl)-6-methyl-pyrimidine (example A.11) (1.0 g, 4.18 mmol) and commercially available 3-bromo-benzene-boronic acid (1.09 g, 5.43 mmol) according to the general procedure IVb. Obtained as an off-white solid (0.5 g, 33%). MS (ISP) 361.0 [(M+H)+]; mp 123° C.

出典と根拠

ORDレコード
ord-b38731ebda2340a0abdd436b0f3017e0
出典データセット
uspto-grants-2012_05
特許番号
US08183262B2

反応ノート

読み込み中…