2-Chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine → 2-(3-Chloro-[1,2,4]triazol-1-yl)-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine
反応式
Cl[C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1[N:24]=[CH:23][NH:22][N:21]=1>>[Cl:19][C:20]1[N:24]=[CH:23][N:22]([C:2]2[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[N:21]=1参加物
3
実験手順
The title compound was prepared from 2-chloro-4-methyl-6-(4-trifluoromethyl-phenyl)-pyrimidine (example A.12) (0.4 g, 1.47 mmol) and commercially available 3-chloro-1H-[1,2,4]triazole (0.22 g, 2.17 mmol) according to the general procedure IVa. Obtained as a yellow solid (0.36 g, 72%). MS (ISP) 340.0 [(M+H)+]; mp 137.5° C.
出典と根拠
- ORDレコード
- ord-43ec60c56fc0419cafadc9a30719efb0
- 出典データセット
- uspto-grants-2012_05