HCID 57468659、化合物 → 4-(3,4-Dichloro-phenyl)-2-(4-iodo-imidazol-1-yl)-6-methyl-pyrimidine
反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=2)[CH:5]=[C:4]([CH3:16])[N:3]=1.[I:17][C:18]1[N:19]=[CH:20][NH:21][CH:22]=1>>[Cl:15][C:10]1[CH:9]=[C:8]([C:6]2[CH:5]=[C:4]([CH3:16])[N:3]=[C:2]([N:21]3[CH:22]=[C:18]([I:17])[N:19]=[CH:20]3)[N:7]=2)[CH:13]=[CH:12][C:11]=1[Cl:14]参加物
3
実験手順
The title compound was prepared from 2-chloro-4-(3,4-dichloro-phenyl)-6-methyl-pyrimidine (example A.41) (3.83 g, 14.0 mmol) and commercially available 4-iodo-imidazole (4.07 g, 21.0 mmol) according to the general procedure IVa. Obtained as a brown solid (1.41 g, 24%). MS (ISP) 431.0 [(M+H)+]; mp 224.5° C.
出典と根拠
- ORDレコード
- ord-88e0aae92ca84914807962391af30e72
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183262B2
反応ノート
読み込み中…