2-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine → HCID 86615445、化合物

反応式

I[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[N:3]=1.[Cl:19][C:20]1(B(O)O)[CH:25]=[CH:24][CH:23]=[CH:22][NH:21]1>>[Cl:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)[N:3]=2)[CH:23]=[CH:22][N:21]=1

参加物

反応物 2

HCID 574686822-Iodo-4-methyl-6-(4-trifluoromethyl-phenyl)pyridine

HCID 68828138HCID 68828138、化合物

生成物 1

HCID 86615445HCID 86615445、化合物

実験手順

The title compound was prepared from 2-iodo-4-methyl-6-(4-trifluoromethyl-phenyl)-pyridine (example A.58) (5.45 g, 15 mmol) and commercially available 2-chloropyridine boronic acid (2.48 g, 15.75 mmol) according to the general procedure IVb. Obtained as an off-white solid (3.82 g, 73%). MS (ISP) 349.2 [(M+H)+] and 351 [(M+2+H)+].

出典と根拠

ORDレコード: ord-41ef4dbe8e89416f9dcefa4d9d39f9c7
出典データセット: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08183262B2

反応ノート

読み込み中…

参加物