HCID 57468683、化合物 → 2'-Chloro-4-(3-methoxy-4-trifluoromethylphenyl)-6-methyl-[2,4']bipyridinyl
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH3:19])[N:16]=[C:15](OS(C(F)(F)F)(=O)=O)[CH:14]=2)[CH:6]=[CH:7][C:8]=1[C:9]([F:12])([F:11])[F:10].[Cl:28][C:29]1(B(O)O)[CH:34]=[CH:33][CH:32]=[CH:31][NH:30]1>>[Cl:28][C:29]1[CH:34]=[C:33]([C:15]2[CH:14]=[C:13]([C:5]3[CH:6]=[CH:7][C:8]([C:9]([F:12])([F:11])[F:10])=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:18]=[C:17]([CH3:19])[N:16]=2)[CH:32]=[CH:31][N:30]=1参加物
3
実験手順
The title compound was prepared from trifluoro-methanesulfonic acid 4-(3-methoxy-4-trifluoromethyl-phenyl)-6-methyl-pyridin-2-yl ester (example A.59) (2.0 g, 5.0 mmol) and commercially available 2-chloropyridine boronic acid (0.758 g, 5.0 mmol) according to the general procedure IVb. Obtained as an off-white solid (1.50 g, 82%). MS (ISP) 379.2 [(M+H)+] and 381 [(M+2+H)+].
出典と根拠
- ORDレコード
- ord-86d670ef154d4b9c9c3652de1601178b
- 出典データセット
- uspto-grants-2012_05