5-Sulfamoylthiophene-2-carboxylic acid → HCID 57468853、化合物

反応式

[OH:1][NH:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)[N:6]=1)=[NH:4].[S:25]([C:29]1[S:30][C:31]([C:34](O)=O)=[CH:32][CH:33]=1)(=[O:28])(=[O:27])[NH2:26]>>[F:14][C:11]([F:12])([F:13])[C:9]1[CH:8]=[C:7]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=2)[N:6]=[C:5]([C:3]2[N:4]=[C:34]([C:31]3[S:30][C:29]([S:25]([NH2:26])(=[O:28])=[O:27])=[CH:33][CH:32]=3)[O:1][N:2]=2)[N:10]=1

参加物

反応物 2

HCID 3410665-Sulfamoylthiophene-2-carboxylic acid

HCID 178513396HCID 178513396、化合物

生成物 1

HCID 57468853HCID 57468853、化合物

実験手順

The title compound was prepared from N-hydroxy-4-trifluoromethyl-6-(4-trifluoromethyl-phenyl)-pyrimidine-2-carboxamidine (example C.2) (0.176 g, 0.5 mmol) and commercially available 2-sulfamoyl-thiophene-5-carboxylic acid [CAS-No. 7353-87-9] (0.104 g, 0.5 mmol) according to the general procedure V. Obtained as a light yellow solid (0.12 g, 46%). MS (ISN) 520.1[(M−H)−]; mp 258.5° C.

出典と根拠

ORDレコード: ord-e1bfdb251cc04e93960f6c58b1021a1c
出典データセット: uspto-grants-2012_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08183262B2

反応ノート

読み込み中…

参加物