Water → Tert-butyl 5-(5-(5-chloropicolinamido)-2-fluorophenyl)-6,6-difluoro-5-methyl-2,5,6,7-tetrahydro-1,4-oxazepin-3-ylcarbamate

HRID 192835

反応式

[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17].[CH3:59][CH2:60][CH2:61][CH2:62][CH2:63][CH3:64].[CH3:65][CH2:66][O:67][C:68](=[O:69])[CH3:70].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:9])[OH:10])[n:6][cH:7]1.[NH2:28][c:29]1[cH:30][cH:31][c:32]([F:53])[c:33]([C:35]2([CH3:52])[N:36]=[C:37]([NH:44][C:45]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:51])[CH2:38][O:39][CH2:40][C:41]2([F:42])[F:43])[cH:34]1.[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[OH2:71].[OH:18][n:19]1[c:20]2[n:21][cH:22][cH:23][cH:24][c:25]2[n:26][n:27]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:10])[NH:28][c:29]2[cH:30][cH:31][c:32]([F:53])[c:33]([C:35]3([CH3:52])[N:36]=[C:37]([NH:44][C:45]([O:46][C:47]([CH3:48])([CH3:49])[CH3:50])=[O:51])[CH2:38][O:39][CH2:40][C:41]3([F:42])[F:43])[cH:34]2)[n:6][cH:7]1