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Morpholine → 4-(1H-imidazol-1-ylsulfonyl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | 3-(1H-Imidazol-1-ylsulfonyl)-1-methyl-1H-imidazolium trifluoromethanesulfonate | HCID 86634166 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 4-(1H-imidazol-1-ylsulfonyl)morpholine | HCID 753836 | 95.1% |
反応手順
3-(1H-Imidazol-1-ylsulfonyl)-1-methyl-1H-imidazolium trifluoromethanesulfonate (1.5 g, 3.0 mmol) was dissolved in acetonitrile (15 mL) and treated with morpholine (0.30 mL, 4.0 mmol) and stirred for 16 h at ambient temperature. The solvent was removed and the residue subjected to column chromatography (silica gel, heptane, ethyl acetate 1:1, 0:1) to yield 4-(imidazole-1-sulfonyl)-morpholine (0.62 g, 83%) as a white solid; MS: m/e=218.5 (M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08183380B2 |
| 出典データセット | uspto-grants-2012_05 |
| ORD ID | ord-084be5e0d8bd47eb9e3ac4f33eaee896 |
| 出典メモ | uspto-grants-2012_05 |