Isobutylene oxide → [1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yl]-carbamic acid ethyl ester
反応式
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8](=[O:12])[O:9][CH2:10][CH3:11])[CH2:3][CH2:2]1.[CH3:13][C:14]1([O:17][CH2:16]1)[CH3:15]>C(O)C>[CH2:10]([O:9][C:8](=[O:12])[NH:7][CH:4]1[CH2:3][CH2:2][N:1]([CH2:13][C:14]([OH:17])([CH3:16])[CH3:15])[CH2:6][CH2:5]1)[CH3:11]参加物
4
実験手順
A mixture of commercially available ethyl piperidin-4-ylcarbamate (2.067 g, 12 mmol) and isobutylene oxide (868 mg, 12 mmol) in ethanol (15 mL) was irradiated in a microwave apparatus at 110° C. for 90 min. Purification by silica gel column chromatography with ethyl acetate gave the title compound as a colorless oil (2.838 g, 97%); MS: m/e=245.3 (M+H+).
後処理
- customwas irradiated in a microwave apparatus at 110° C. for 90 min
- customPurification by silica gel column chromatography with ethyl acetate
出典と根拠
- ORDレコード
- ord-7bc56b8899dd4890b9e22e4953127a5f
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183380B2
反応ノート
読み込み中…