(R)-1,2-Epoxypropane → HCID 66841391、化合物
反応式
[CH3:1][C@@H:2]1[C@@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH2:6][CH2:5][NH:4][CH2:3]1.[CH3:15][C@@H:16]1[CH2:18][O:17]1>C(O)C>[OH:17][C@H:16]([CH3:18])[CH2:15][N:4]1[CH2:5][CH2:6][C@H:7]([O:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[C@@H:2]([CH3:1])[CH2:3]1参加物
4
実験手順
A solution of piperidine 17 (2 g, 10.8 mmol) and (R)-2-Methyl-oxirane (3.78 ml, 54 mmol) in 2 ml of ethanol is stirred for 24 hours in a closed flask. The solvent is evaporated and the residue distilled in a Kugelrohr apparatus (0.08 mbar, 75-90 C).
後処理
- customThe solvent is evaporated
- distillationthe residue distilled in a Kugelrohr apparatus (0.08 mbar, 75-90 C)
出典と根拠
- ORDレコード
- ord-6a34476b1cd344208f2406919a32f1a4
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08183366B2
反応ノート
読み込み中…