Ethanol → 4-Cyclopentylmethoxy-1H-indole-2-carboxylic acid

HRID 1929056ノート

反応式

HRID 1929056 の反応式
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([O:15][CH2:16][CH:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)[CH:11]=[CH:10][CH:9]=2)=[O:5])C.[OH-].[K+].CCO>>[CH:17]1([CH2:16][O:15][C:12]2[CH:11]=[CH:10][CH:9]=[C:8]3[C:13]=2[CH:14]=[C:6]([C:4]([OH:5])=[O:3])[NH:7]3)[CH2:18][CH2:19][CH2:20][CH2:21]1

参加物

4

反応物 3

HCID 702EthanolHCID 14797Potassium HydroxideHCID 668413514-Cyclopentylmethoxy-1H-indole-2-carboxylic acid ethyl ester

生成物 1

HCID 668411204-Cyclopentylmethoxy-1H-indole-2-carboxylic acid

実験手順

The 4-cyclopentylmethoxy-1H-indole-2-carboxylic acid ethyl ester 87 obtained above is mixed with a 2M-solution of KOH in EtOH (33.8 ml, 67.6 mmol) and stirred for 24 hours. The solvent is then evaporated and the residue is partitioned between water and ether. The water layer is acidified with HCl and extracted twice with EtOAc. The combined organic layers are washed with brine, dried over anhydrous sodium sulfate, filtered and evaporated to give a white powder.

後処理

  1. customThe solvent is then evaporated
  2. customthe residue is partitioned between water and ether
  3. extractionextracted twice with EtOAc
  4. washThe combined organic layers are washed with brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. filtrationfiltered
  7. customevaporated
  8. customto give a white powder

出典と根拠

ORDレコード
ord-3e346ee9b96a467d8eb34d7134abddd4
出典データセット
uspto-grants-2012_05
特許番号
US08183366B2

反応ノート

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