Malonic Acid → 3-(2,4-Difluoro-3-methyl-phenyl)-acrylic acid
反応式
[F:1][C:2]1[C:9]([CH3:10])=[C:8]([F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=O.C(O)(=O)[CH2:13][C:14]([OH:16])=[O:15]>>[F:1][C:2]1[C:9]([CH3:10])=[C:8]([F:11])[CH:7]=[CH:6][C:3]=1[CH:4]=[CH:13][C:14]([OH:16])=[O:15]参加物
3
実験手順
According to the previously described general procedure (GP1), Knoevenagel condensation (75° C.; 3h30) between 2,4-difluoro-3-methyl-benzaldehyde (1.560 g; 9.744 mmol) and malonic acid (1.926 g; 18.515 mmol) gave the product 3-(2,4-difluoro-3-methyl-phenyl)-acrylic acid as a pale yellow solid (1.600 g; 83%). LC-MS: tR=0.86 min; [M+H]+: no ionisation.
出典と根拠
- ORDレコード
- ord-df10f7ca732c48608ccd88a057c12193
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08188082B2
反応ノート
読み込み中…