2-(4-Iodo-2-methyl-imidazol-1-yl)-ethylamine → HCID 66733870、化合物

HRID 1929655ノート

反応式

HRID 1929655 の反応式
[I:1][C:2]1[N:3]=[C:4]([CH3:10])[N:5]([CH2:7][CH2:8][NH2:9])[CH:6]=1.[F:11][C:12]1[CH:13]=[C:14]([CH2:20][CH2:21][CH:22]=O)[CH:15]=[C:16]([F:19])[C:17]=1[CH3:18]>>[F:11][C:12]1[CH:13]=[C:14]([CH2:20][CH2:21][CH:22]2[NH:9][CH2:8][CH2:7][N:5]3[C:4]([CH3:10])=[N:3][C:2]([I:1])=[C:6]23)[CH:15]=[C:16]([F:19])[C:17]=1[CH3:18]

参加物

3

反応物 2

HCID 667339802-(4-Iodo-2-methyl-imidazol-1-yl)-ethylamineHCID 730140753-(3,5-Difluoro-4-methylphenyl)propionaldehyde

生成物 1

HCID 66733870HCID 66733870、化合物

実験手順

According to the general procedure (GP10), the microwave-assisted Pictet-Spengler reaction (60 W; 110° C.; 5 bars; 10 min.) between 2-(4-iodo-2-methyl-imidazol-1-yl)-ethylamine (696 mg; 2.774 mmol) and 3-(3,5-difluoro-4-methyl-phenyl)-propionaldehyde (510 mg; 2.774 mmol) afforded 8-[2-(3,5-difluoro-4-methyl-phenyl)-ethyl]-1-iodo-3-methyl-5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine which was Boc-protected and finally purified by FC (DCM/MeOH=25/1).

出典と根拠

ORDレコード
ord-0f58c94c0e474048974b1b7f0dbf4277
出典データセット
uspto-grants-2012_05
特許番号
US08188082B2

反応ノート

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