Ammonium Acetate → 7-Bromo-6-fluoro-1,2-dihydroisoquinolin-1-one

HRID 1930219ノート

反応式

HRID 1930219 の反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]=[C:9]2Cl)=[CH:4][C:3]=1[F:13].C([O-])(=[O:16])C.[NH4+]>C(O)(=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][NH:8][C:9]2=[O:16])=[CH:4][C:3]=1[F:13]

参加物

4

反応物 2

HCID 517165Ammonium AcetateHCID 598182627-Bromo-1-chloro-6-fluoroisoquinoline

生成物 1

HCID 598182537-Bromo-6-fluoro-1,2-dihydroisoquinolin-1-one収率 83%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
100 °C

実験手順

12.9 g (49.5 mmol) 7-bromo-1-chloro-6-fluoro-isoquinoline (311) were dissolved in 250 mL of acetic acid. After adding 38.7 g (0.5 mol) ammonium acetate, the solution was stirred at 100° C. After 3 h, the solvent was removed i. vac. and the residue was poured on water. The precipitate was filtered and dried to yield 9.91 g (83%) of the title compound. Rt=1.15 min (Method C). Detected mass: 242.2/244.1 (M+H+).

後処理

  1. customthe solvent was removed i
  2. additionand the residue was poured on water
  3. filtrationThe precipitate was filtered
  4. customdried

出典と根拠

ORDレコード
ord-e59befaa23aa446cb0844059c8df8d73
出典データセット
uspto-grants-2012_05
特許番号
US08188117B2

反応ノート

読み込み中…