Hydrochloric Acid → HCID 178493227、化合物

関与物質

反応手順

3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline hydrochloride (3 g, 12.52 mmol), cyanamide (0.684 g, 16.27 mmol) and hydrochloric acid (1.564 mL, 18.77 mmol) in ethanol (20 mL) were heated to reflux o.n. The reaction mixture was concentrated under reduced pressure before the resulting mixture was poured on a solution of potassium carbonate (1.730 g, 12.52 mmol) in water (60 mL) and left in refrigerator o.n. The formed carbonate-salt was filtered off, and dried in vacuum oven o.n. The solid was washed with several portions of DCM, dried and used as such in next step.

情報源と証拠