Potassium Carbonate → 1-(2-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)ethyl)pyrrolidin-2-one

HRID 1930719ノート

反応式

HRID 1930719 の反応式
O=[C:2]([CH:11]1[C:16](=O)[CH2:15][CH2:14][O:13][CH2:12]1)[CH2:3][CH2:4][N:5]1[CH2:9][CH2:8][CH2:7][C:6]1=[O:10].[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:32][C:33]([NH2:35])=[NH:34])[CH:23]=[CH:24][C:25]=1[N:26]1[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]1.C(=O)([O-])[O-].[K+].[K+]>CCO>[CH3:18][O:19][C:20]1[CH:21]=[C:22]([NH:32][C:33]2[N:35]=[C:2]([CH2:3][CH2:4][N:5]3[CH2:9][CH2:8][CH2:7][C:6]3=[O:10])[C:11]3[CH2:12][O:13][CH2:14][CH2:15][C:16]=3[N:34]=2)[CH:23]=[CH:24][C:25]=1[N:26]1[CH:30]=[C:29]([CH3:31])[N:28]=[CH:27]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 59333778HCID 59333778、化合物HCID 178493227HCID 178493227、化合物

生成物 1

HCID 593337661-(2-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-4-yl)ethyl)pyrrolidin-2-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-(3-oxo-3-(4-oxotetrahydro-2H-pyran-3-yl)propyl)pyrrolidin-2-one (202 mg, 0.84 mmol), 1-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)guanidine (1 equiv.) and potassium carbonate (2 equiv.) were heated to 50° C. over night in EtOH (5 mL). The crude product was extracted into DCM and solvent was evaporated. The crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes) followed by prepHPLC to afford the titled compound.

後処理

  1. extractionThe crude product was extracted into DCM and solvent
  2. customwas evaporated
  3. customThe crude product was purified by flash chromatogaphy (0-100% EtOAc in heptanes)

出典と根拠

ORDレコード
ord-0dfd971067b4487081acab2d07b9b480
出典データセット
uspto-grants-2012_05
特許番号
US08188101B2

反応ノート

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