Water → 3-Butyl-5,5-dimethylthiazolidin-2-imine

HRID 1931106ノート

反応式

HRID 1931106 の反応式
[CH3:1][C:2]1([CH3:5])[CH2:4][S:3]1.[CH2:6]([NH:10][C:11]#[N:12])[CH2:7][CH2:8][CH3:9].C(=O)([O-])[O-].[K+].[K+].O>CC(=O)CC>[CH2:6]([N:10]1[CH2:4][C:2]([CH3:1])([CH3:5])[S:3][C:11]1=[NH:12])[CH2:7][CH2:8][CH3:9]

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 1380502,2-DimethylthiiraneHCID 12295218Butylcyanamide

生成物 1

HCID 666431113-Butyl-5,5-dimethylthiazolidin-2-imine収率 66.6%

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

反応条件

温度
80 °C

実験手順

A mixture of 2,2-dimethyl-thiirane (TCI, 1.5 g, 17 mmol), N-butyl-cyanamide (1.7 g, 17 mmol) (prepared as described in Ross J. Med. Chem. 1979, 22; 412) and potassium carbonate (2.4 g, 17 mmol) in 2-butanone (15 mL) was heated to 80° C. overnight. The mixture was poured into water, and extracted twice with ethyl acetate. The combined organic extracts were dried over Na2SO4, filtered, concentrated under reduced pressure to afford 2.11 g of the title compound.

後処理

  1. extractionextracted twice with ethyl acetate
  2. dry with materialThe combined organic extracts were dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-10f343c3722f48e4acdb7c9affbb506e
出典データセット
uspto-grants-2012_05
特許番号
US08188135B2

反応ノート

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