Piperidine → HCID 59152239、化合物

HRID 1931403ノート

反応式

HRID 1931403 の反応式
[O:1]=[C:2]1[O:6][C:5]([CH2:7][CH2:8][C:9]([OH:11])=O)=[N:4][N:3]1[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[B-](F)(F)(F)F.CCOC(C(C#N)=NOC(N(C)C)=[N+](C)C)=O.[NH:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>CN(C=O)C>[O:11]=[C:9]([N:40]1[CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1)[CH2:8][CH2:7][C:5]1[O:6][C:2](=[O:1])[N:3]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:4]=1

参加物

5

反応物 3

HCID 8082PiperidineHCID 2733286O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborateHCID 68536689HCID 68536689、化合物

生成物 1

HCID 59152239HCID 59152239、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

50 mg (0.21 mmol) of 3-(5-oxo-4-phenyl-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-propionic acid, 245 mg (2.13 mmol) of NEM and 77 mg (0.23 mmol) of TOTU were dissolved in 2 ml of DMF and stirred at room temperature for 15 min. 20 mg (0.23 mmol) of piperidine were added, and the reaction mixture was stirred at room temperature for 16 h. After evaporation, the product was purified by silica gel chromatography. Yield: 45 mg.

後処理

  1. stirringthe reaction mixture was stirred at room temperature for 16 h
  2. customAfter evaporation
  3. customthe product was purified by silica gel chromatography

出典と根拠

ORDレコード
ord-d604148a44ad456087b724ecefa82405
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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