2-Aminothiazole → 2-[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-N-(thiazol-2-yl)-acetamide trifluoroacetic acid salt

HRID 1931464ノート

反応式

HRID 1931464 の反応式
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([OH:25])=O)=[CH:17][CH:16]=2)=[CH:11][CH:10]=1.[NH2:26][C:27]1[S:28][CH:29]=[CH:30][N:31]=1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[N:20]=[CH:19][C:18]([O:21][CH2:22][C:23]([NH:26][C:27]3[S:28][CH:29]=[CH:30][N:31]=3)=[O:25])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1

参加物

3

反応物 2

HCID 21552-AminothiazoleHCID 68534898[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt

生成物 1

HCID 866381372-[6-(4-Fluoro-phenyl)-pyridin-3-yloxy]-N-(thiazol-2-yl)-acetamide trifluoroacetic acid salt

実験手順

The title compound was prepared analogously as described in Example 30(d) from 95 mg (0.26 mmol) of [6-(4-fluoro-phenyl)-pyridin-3-yloxy]-acetic acid trifluoroacetic acid salt and 39.5 mg (0.39 mmol) of 2-aminothiazole. Yield: 20 mg.

出典と根拠

ORDレコード
ord-1f736adfa89d47efb8db5c64765d210f
出典データセット
uspto-grants-2012_05
特許番号
US08188291B2

反応ノート

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