Dimethylformamide diethylacetal → HCID 178484332、化合物
反応式
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[O:8])=[CH:5][CH:4]=1)#[N:2].C(O[CH:15](OCC)[N:16]([CH3:18])[CH3:17])C>>[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7](/[N:9]=[CH:15]/[N:16]([CH3:18])[CH3:17])=[O:8])=[CH:5][CH:4]=1)#[N:2]参加物
3
反応条件
- 温度
- 120 °C
実験手順
4-cyanobenzamide (327.0 mg, 2.237 mmol) and N,N-dimethylformamide diethyl acetal (0.53 ml, 3.09 mmol) were combined and heated to 120° C. A short path distillation apparatus was used to collect the ethanol that was liberated during the reaction. The reaction mixture was a dark purple solution that slowly turned lighter until it had become an amber solution. After 70 minutes, the reaction mixture solidified. The reaction mixture was cooled to room temperature and was placed under high vacuum overnight to give the title compound (432.7 mg, 2.150 mmol) as a yellow solid.
後処理
- distillation