Hydrochloric Acid → 2-Amino-4,4-difluorobutanoic acid hydrochloride

HRID 19323ノート

反応式

HRID 19323 の反応式
C([O:3][C:4](=[O:19])[C:5]([NH:15]C(=O)C)([CH2:11][CH:12]([F:14])[F:13])C(OCC)=O)C.[ClH:20]>>[ClH:20].[NH2:15][CH:5]([CH2:11][CH:12]([F:14])[F:13])[C:4]([OH:19])=[O:3]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 17749984Diethyl 2-acetamido-2-(2,2-difluoroethyl)malonate

生成物 1

HCID 470033322-Amino-4,4-difluorobutanoic acid hydrochloride収率 97%

実験手順

In a flask was placed 2-acetylamino-2-(2,2-difluoro-ethyl)-malonic acid diethyl ester (8.94 g, 31.78 mmol) and 6N aqueous hydrochloric acid (140 mL). This mixture was refluxed overnight. After this time, the mixture was cooled to room temperature and extracted with diethyl ether (100 mL) the aqueous layer was concentrated in vacuo, azeotroped with acetonitrile and dried under high vacuum to afford 2-amino-4,4-difluoro-butyric acid hydrochloride salt (5.39 g, 97%) as a cream colored solid.

後処理

  1. customIn a flask was placed
  2. temperatureThis mixture was refluxed overnight
  3. extractionextracted with diethyl ether (100 mL) the aqueous layer
  4. concentrationwas concentrated in vacuo
  5. customazeotroped with acetonitrile
  6. customdried under high vacuum

出典と根拠

ORDレコード
ord-c9fda19b50b74a45a68557364533658c
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

反応ノート

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