Acetyl chloride → 6-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline

HRID 1932307ノート

反応式

HRID 1932307 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][CH2:6][NH2:7].[C:11](Cl)(=O)[CH3:12]>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[CH:11]([CH3:12])[NH:7][CH2:6][CH2:5]2

参加物

3

反応物 2

HCID 6367Acetyl chlorideHCID 5339282-(3-Fluorophenyl)ethanamine

生成物 1

HCID 115138056-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline

実験手順

In accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21, except for using 3-fluorophenethylamine and acetyl chloride, 6-fluoro-1-methyl-1,2,3,4-tetrahydroisoquinoline was obtained. In accordance with the same procedures as in Preparation 20, the titled compound was obtained as pale yellow oil. (Yield: 55%) The product was used in the subsequent step without further purification.

後処理

  1. customIn accordance with the same procedures as in Steps 1, 2, and 3 of Preparation 21

出典と根拠

ORDレコード
ord-9c382d635ed04de49906d8eaa51d1f8a
出典データセット
uspto-grants-2012_05
特許番号
US08188114B2

反応ノート

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