化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Carbonate → 4-(3-Bromophenylmethylamino)-6,7-diethoxy-3-quinolinecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Benzenemethanamine, 3-bromo- | HCID 457587 | — |
| 反応物 | 1-Ethoxyethanol | HCID 10129898 | — |
| 反応物 | 4-Chloro-6,7-diethoxyquinoline-3-carbonitrile | HCID 10778872 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | 4-(3-Bromophenylmethylamino)-6,7-diethoxy-3-quinolinecarbonitrile | HCID 22466686 | 68.5% |
反応手順
A stirred mixture of 4-chloro-6,7-diethoxy-3-quinolinecarbonitrile (0.69 g, 2.5 mmol), 3-bromobenzylamine (0.78 g, 3.5 mmol), diisopropylethyl amine (1.05 ml, 6.0 mmol), and 7.5 ml of ethoxyethanol was refluxed for 4 h, cooled, and stirred with a mixture of hexane and water containing 0.4 g of potassium carbonate for 3 h. The resulting solid was filtered, washed with water, and dried. Recrystallization from acetone-hexane gave 0.73 g of off-white solid, mp 156-159° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06384051B1 |
| 出典データセット | uspto-grants-2002_05 |
| ORD ID | ord-a581f93e538b49cf8efb821ae04a6692 |
| 出典メモ | uspto-grants-2002_05 |