関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 9H-Fluoren-9-one, 2-fluoro- | HCID 96016 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | 2-Fluorofluorene | HCID 241132 | — |
反応手順
2-Fluoro-9-fluorenone, 20 (1.78 gms, 8.9 mmol) was dissolved in ethylene glycol(60 mL) under a nitrogen atmosphere. Hydrazine hydrate(1.8 mL) was added and the mixture was heated at 180° C. for two hours. The mixture was then cooled and poured into water. The aqueous layer was extracted with ethyl acetate and the organic layer was washed with brine, dried over sodium sulfate, filtered, and concentrated to yield the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06387893B1 |
|---|
| 出典データセット | uspto-grants-2002_05 |
|---|
| ORD ID | ord-88062313c62a46fcb049910b9140c534 |
|---|
| 出典メモ | uspto-grants-2002_05 |
|---|
